CovidChloroV1, Main, Exploration, bibRecord, 001753

COVID-19 infection in first trimester of pregnancy marked by a liver cytolysis in a woman previously treated by hydroxychloroquine for repeated implantation failure: a case report.

Identifieur interne : 001753 ( Main/Exploration ); précédent : 001752; suivant : 001754

COVID-19 infection in first trimester of pregnancy marked by a liver cytolysis in a woman previously treated by hydroxychloroquine for repeated implantation failure: a case report.

Auteurs : F. Lamazou [France] ; P. Oger [France] ; R. Dieli-Crimi [Espagne] ; A. Guerin [Espagne] ; V. Letouzey [France] ; S. Octernaud [France] ; V. Place [France] ; P. Calès [France] ; P. Descamps [France] ; L. Delaroche [France]

Source :

BMC infectious diseases [ 1471-2334 ] ; 2020.

RBID : pubmed:33198681

Descripteurs français

KwdFr :
- ARN viral (isolement et purification), Adulte (MeSH), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Betacoronavirus (génétique), Betacoronavirus (isolement et purification), Chine (MeSH), Complications infectieuses de la grossesse (anatomopathologie), Diagnostic différentiel (MeSH), Femelle (MeSH), Foie (anatomopathologie), Foie (enzymologie), Grossesse (MeSH), Humains (MeSH), Hydroxychloroquine (pharmacologie), Hydroxychloroquine (usage thérapeutique), Implantation embryonnaire (effets des médicaments et des substances chimiques), Infections à coronavirus (anatomopathologie), Pandémies (MeSH), Pneumopathie virale (anatomopathologie), Premier trimestre de grossesse (MeSH), Réaction de polymérisation en chaine en temps réel (MeSH), Transaminases (métabolisme).
MESH :
- anatomopathologie : Complications infectieuses de la grossesse, Foie, Infections à coronavirus, Pneumopathie virale.
- effets des médicaments et des substances chimiques : Implantation embryonnaire.
- enzymologie : Foie.
- génétique : Betacoronavirus.
- isolement et purification : ARN viral, Betacoronavirus.
- métabolisme : Transaminases.
- pharmacologie : Antiviraux, Hydroxychloroquine.
- usage thérapeutique : Antiviraux, Hydroxychloroquine.
- Adulte, Chine, Diagnostic différentiel, Femelle, Grossesse, Humains, Pandémies, Premier trimestre de grossesse, Réaction de polymérisation en chaine en temps réel.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Adult (MeSH), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Betacoronavirus (genetics), Betacoronavirus (isolation & purification), COVID-19 (MeSH), China (MeSH), Coronavirus Infections (pathology), Diagnosis, Differential (MeSH), Embryo Implantation (drug effects), Female (MeSH), Humans (MeSH), Hydroxychloroquine (pharmacology), Hydroxychloroquine (therapeutic use), Liver (enzymology), Liver (pathology), Pandemics (MeSH), Pneumonia, Viral (pathology), Pregnancy (MeSH), Pregnancy Complications, Infectious (pathology), Pregnancy Trimester, First (MeSH), RNA, Viral (isolation & purification), Real-Time Polymerase Chain Reaction (MeSH), SARS-CoV-2 (MeSH), Transaminases (metabolism).
MESH :
- chemical , isolation & purification : RNA, Viral.
- chemical , metabolism : Transaminases.
- chemical , pharmacology : Antiviral Agents, Hydroxychloroquine.
- chemical , therapeutic use : Antiviral Agents, Hydroxychloroquine.
- geographic : China.
- drug effects : Embryo Implantation.
- enzymology : Liver.
- genetics : Betacoronavirus.
- isolation & purification : Betacoronavirus.
- pathology : Coronavirus Infections, Liver, Pneumonia, Viral, Pregnancy Complications, Infectious.
- Adult, COVID-19, Diagnosis, Differential, Female, Humans, Pandemics, Pregnancy, Pregnancy Trimester, First, Real-Time Polymerase Chain Reaction, SARS-CoV-2.

Abstract

BACKGROUND

In December 2019, a new disease (COVID-19) caused by a novel coronavirus called SARS-CoV-2 emerged in China and spread to many other countries. There is only limited data about the clinical features of COVID-19 during pregnancy, especially in first trimester.

CASE PRESENTATION

We report a COVID-19 infection in a 35 years-old patient in first trimester of pregnancy and its consequent medical care. At 7 weeks of pregnancy, the patient, who did not have any pregestational comorbidities, complained of intense nausea and asthenia. An important liver cytolysis was discovered with biological perturbations of transaminases levels. No respiratory symptoms were recorded. Classical viral aetiologies and drug-related toxicity were discarded. Because of the aggravation of the symptoms and the occurrence of the breathlessness, the patient was tested for the COVID-19 in a nasopharyngeal swab. The RTq-PCR assay indicated the presence of SARS-CoV-2 RNA. In the absence of severe symptoms, the patient was monitored at home according to the French government guidelines. After a few days, the symptoms resolved without any complications. The pregnancy is still ongoing without any visible sequelae on the foetus so far.

CONCLUSIONS

This first case illustrated the difficulty of COVID-19 diagnosis in patients with isolated digestive symptoms in first trimester of pregnancy that could be confused with gravida hyperemesis. Monitoring of pregnancy after an episode of COVID-19 should be strengthened with bimonthly foetal growth ultrasounds and doppler assessments because of the risks for intrauterine growth restriction. Comprehensive data on larger numbers of first trimester gravid women with COVID-19 are required to better understanding the overall impact of SARS-CoV-2 on maternal and birth outcomes.

DOI: 10.1186/s12879-020-05551-0
PubMed: 33198681
PubMed Central: PMC7667476

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000820
to stream Main, to step Curation: 000820

Le document en format XML

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<author><name sortKey="Oger, P" sort="Oger, P" uniqKey="Oger P" first="P" last="Oger">P. Oger</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Dieli Crimi, R" sort="Dieli Crimi, R" uniqKey="Dieli Crimi R" first="R" last="Dieli-Crimi">R. Dieli-Crimi</name>
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<author><name sortKey="Letouzey, V" sort="Letouzey, V" uniqKey="Letouzey V" first="V" last="Letouzey">V. Letouzey</name>
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<author><name sortKey="Octernaud, S" sort="Octernaud, S" uniqKey="Octernaud S" first="S" last="Octernaud">S. Octernaud</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Medical Radiology center Juras, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<author><name sortKey="Place, V" sort="Place, V" uniqKey="Place V" first="V" last="Place">V. Place</name>
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<author><name sortKey="Cales, P" sort="Cales, P" uniqKey="Cales P" first="P" last="Calès">P. Calès</name>
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<author><name sortKey="Descamps, P" sort="Descamps, P" uniqKey="Descamps P" first="P" last="Descamps">P. Descamps</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Ob-Gyn, Angers University Hospital, 4 rue Larrey, 49933, Angers Cedex 09, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Ob-Gyn, Angers University Hospital, 4 rue Larrey, 49933, Angers Cedex 09</wicri:regionArea>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Angers</settlement>
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<affiliation wicri:level="3"><nlm:affiliation>Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université Montpellier, ENSCM, 34093, Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Delaroche, L" sort="Delaroche, L" uniqKey="Delaroche L" first="L" last="Delaroche">L. Delaroche</name>
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<country xml:lang="fr">France</country>
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<affiliation wicri:level="3"><nlm:affiliation>Centre de biologie médicale de l'Hôpital Privé de Parly 2, 21 rue Moxouris, 78150, Le Chesnay, France.</nlm:affiliation>
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<series><title level="j">BMC infectious diseases</title>
<idno type="eISSN">1471-2334</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Betacoronavirus (genetics)</term>
<term>Betacoronavirus (isolation & purification)</term>
<term>COVID-19 (MeSH)</term>
<term>China (MeSH)</term>
<term>Coronavirus Infections (pathology)</term>
<term>Diagnosis, Differential (MeSH)</term>
<term>Embryo Implantation (drug effects)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (pharmacology)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Liver (enzymology)</term>
<term>Liver (pathology)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (pathology)</term>
<term>Pregnancy (MeSH)</term>
<term>Pregnancy Complications, Infectious (pathology)</term>
<term>Pregnancy Trimester, First (MeSH)</term>
<term>RNA, Viral (isolation & purification)</term>
<term>Real-Time Polymerase Chain Reaction (MeSH)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Transaminases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (isolement et purification)</term>
<term>Adulte (MeSH)</term>
<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Betacoronavirus (génétique)</term>
<term>Betacoronavirus (isolement et purification)</term>
<term>Chine (MeSH)</term>
<term>Complications infectieuses de la grossesse (anatomopathologie)</term>
<term>Diagnostic différentiel (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Foie (anatomopathologie)</term>
<term>Foie (enzymologie)</term>
<term>Grossesse (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hydroxychloroquine (pharmacologie)</term>
<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Implantation embryonnaire (effets des médicaments et des substances chimiques)</term>
<term>Infections à coronavirus (anatomopathologie)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (anatomopathologie)</term>
<term>Premier trimestre de grossesse (MeSH)</term>
<term>Réaction de polymérisation en chaine en temps réel (MeSH)</term>
<term>Transaminases (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Transaminases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Complications infectieuses de la grossesse</term>
<term>Foie</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Embryo Implantation</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Implantation embryonnaire</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Foie</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>ARN viral</term>
<term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Transaminases</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Liver</term>
<term>Pneumonia, Viral</term>
<term>Pregnancy Complications, Infectious</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>COVID-19</term>
<term>Diagnosis, Differential</term>
<term>Female</term>
<term>Humans</term>
<term>Pandemics</term>
<term>Pregnancy</term>
<term>Pregnancy Trimester, First</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>SARS-CoV-2</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Chine</term>
<term>Diagnostic différentiel</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Pandémies</term>
<term>Premier trimestre de grossesse</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>In December 2019, a new disease (COVID-19) caused by a novel coronavirus called SARS-CoV-2 emerged in China and spread to many other countries. There is only limited data about the clinical features of COVID-19 during pregnancy, especially in first trimester.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CASE PRESENTATION</b>
</p>
<p>We report a COVID-19 infection in a 35 years-old patient in first trimester of pregnancy and its consequent medical care. At 7 weeks of pregnancy, the patient, who did not have any pregestational comorbidities, complained of intense nausea and asthenia. An important liver cytolysis was discovered with biological perturbations of transaminases levels. No respiratory symptoms were recorded. Classical viral aetiologies and drug-related toxicity were discarded. Because of the aggravation of the symptoms and the occurrence of the breathlessness, the patient was tested for the COVID-19 in a nasopharyngeal swab. The RTq-PCR assay indicated the presence of SARS-CoV-2 RNA. In the absence of severe symptoms, the patient was monitored at home according to the French government guidelines. After a few days, the symptoms resolved without any complications. The pregnancy is still ongoing without any visible sequelae on the foetus so far.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>This first case illustrated the difficulty of COVID-19 diagnosis in patients with isolated digestive symptoms in first trimester of pregnancy that could be confused with gravida hyperemesis. Monitoring of pregnancy after an episode of COVID-19 should be strengthened with bimonthly foetal growth ultrasounds and doppler assessments because of the risks for intrauterine growth restriction. Comprehensive data on larger numbers of first trimester gravid women with COVID-19 are required to better understanding the overall impact of SARS-CoV-2 on maternal and birth outcomes.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>11</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>12</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2334</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>20</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>Nov</Month>
<Day>16</Day>
</PubDate>
</JournalIssue>
<Title>BMC infectious diseases</Title>
<ISOAbbreviation>BMC Infect Dis</ISOAbbreviation>
</Journal>
<ArticleTitle>COVID-19 infection in first trimester of pregnancy marked by a liver cytolysis in a woman previously treated by hydroxychloroquine for repeated implantation failure: a case report.</ArticleTitle>
<Pagination><MedlinePgn>845</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12879-020-05551-0</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In December 2019, a new disease (COVID-19) caused by a novel coronavirus called SARS-CoV-2 emerged in China and spread to many other countries. There is only limited data about the clinical features of COVID-19 during pregnancy, especially in first trimester.</AbstractText>
<AbstractText Label="CASE PRESENTATION" NlmCategory="METHODS">We report a COVID-19 infection in a 35 years-old patient in first trimester of pregnancy and its consequent medical care. At 7 weeks of pregnancy, the patient, who did not have any pregestational comorbidities, complained of intense nausea and asthenia. An important liver cytolysis was discovered with biological perturbations of transaminases levels. No respiratory symptoms were recorded. Classical viral aetiologies and drug-related toxicity were discarded. Because of the aggravation of the symptoms and the occurrence of the breathlessness, the patient was tested for the COVID-19 in a nasopharyngeal swab. The RTq-PCR assay indicated the presence of SARS-CoV-2 RNA. In the absence of severe symptoms, the patient was monitored at home according to the French government guidelines. After a few days, the symptoms resolved without any complications. The pregnancy is still ongoing without any visible sequelae on the foetus so far.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This first case illustrated the difficulty of COVID-19 diagnosis in patients with isolated digestive symptoms in first trimester of pregnancy that could be confused with gravida hyperemesis. Monitoring of pregnancy after an episode of COVID-19 should be strengthened with bimonthly foetal growth ultrasounds and doppler assessments because of the risks for intrauterine growth restriction. Comprehensive data on larger numbers of first trimester gravid women with COVID-19 are required to better understanding the overall impact of SARS-CoV-2 on maternal and birth outcomes.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lamazou</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-5248-8613</Identifier>
<AffiliationInfo><Affiliation>Ramsay Générale de Santé, Hôpital Privé de Parly 2, Institut Fertilité Maternité Parly 2, 21 rue Moxouris, 78150, Le Chesnay, France. dr.lamazou@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oger</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Ramsay Générale de Santé, Hôpital Privé de Parly 2, Institut Fertilité Maternité Parly 2, 21 rue Moxouris, 78150, Le Chesnay, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dieli-Crimi</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Immunology Division, Hospital Universitari Vall d'Hebron (HUVH), Vall d'Hebron Research Institute (VHIR), Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona (UAB), Barcelona, Catalonia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jeffrey Model Foundation Excellence Center, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guerin</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>IVI, Ronda General Mitre, 14, 08017, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Letouzey</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, University Hospital Caremeau, Nîmes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Octernaud</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Medical Radiology center Juras, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Place</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Medical Radiology center Juras, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Calès</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Hepato-Gastroenterology Department, University Hospital, Angers, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>HIFIH laboratory, UPRES 3859, UNIV Angers, Angers, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Descamps</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Ob-Gyn, Angers University Hospital, 4 rue Larrey, 49933, Angers Cedex 09, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université Montpellier, ENSCM, 34093, Montpellier, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Delaroche</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Ramsay Générale de Santé, Hôpital Privé de Parly 2, Institut Fertilité Maternité Parly 2, 21 rue Moxouris, 78150, Le Chesnay, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre de biologie médicale de l'Hôpital Privé de Parly 2, 21 rue Moxouris, 78150, Le Chesnay, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>11</Month>
<Day>16</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>BMC Infect Dis</MedlineTA>
<NlmUniqueID>100968551</NlmUniqueID>
<ISSNLinking>1471-2334</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber>
<NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.6.1.-</RegistryNumber>
<NameOfSubstance UI="D000637">Transaminases</NameOfSubstance>
</Chemical>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010064" MajorTopicYN="N">Embryo Implantation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011251" MajorTopicYN="N">Pregnancy Complications, Infectious</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011261" MajorTopicYN="N">Pregnancy Trimester, First</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000637" MajorTopicYN="N">Transaminases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Case report</Keyword>
<Keyword MajorTopicYN="N">First trimester</Keyword>
<Keyword MajorTopicYN="N">Hepatic cytolysis</Keyword>
<Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword>
<Keyword MajorTopicYN="N">Liver</Keyword>
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<Month>05</Month>
<Day>28</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>10</Month>
<Day>27</Day>
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<Day>17</Day>
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<ReferenceList><Reference><Citation>Lancet Gastroenterol Hepatol. 2020 May;5(5):428-430</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32145190</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Fetal Pediatr Pathol. 2020 Jun;39(3):246-250</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32238084</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Mar 7;395(10226):760-762</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32151334</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Travel Med Infect Dis. 2020 Mar - Apr;34:101663</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32289548</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gastroenterol Hepatol. 2020 May;35(5):744-748</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32215956</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Med Sci. 2020 Apr;40(2):285-289</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32219626</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Aliment Pharmacol Ther. 2020 May;51(9):843-851</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32222988</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Coll Cardiol. 2020 Jun 16;75(23):2950-2973</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32311448</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lupus. 2015 May;24(6):638-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25424894</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Obstet Gynecol Scand. 2020 Jul;99(7):823-829</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32259279</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Virol. 2020 Jun;127:104356</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32302955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Feb 20;382(8):727-733</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31978945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Obstet Gynecol. 2020 Jul;223(1):111.e1-111.e14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32335053</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Gastroenterol Hepatol. 2020 Jun;18(7):1636-1637</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32205220</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Gastroenterol Hepatol. 2020 Jun;5(6):529-530</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32203680</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2020 May;55(5):105960</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32251731</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Rheumatol. 2020 Jul;39(7):2055-2062</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32277367</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2020 Jun;20(6):669-677</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32240634</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Reprod Immunol. 2020 Jun;139:103121</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32240947</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Med. 2020 Apr;14(2):193-198</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32285380</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Thromb Haemost. 2020 Jun;18(6):1521-1522</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32302456</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Pathol Lab Med. 2020 Mar 17;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32180426</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MMWR Morb Mortal Wkly Rep. 2020 Jun 26;69(25):769-775</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32584795</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Obstet Gynecol. 2020 May;222(5):415-426</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32105680</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transl Pediatr. 2020 Feb;9(1):51-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32154135</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Med. 2020 Apr;14(2):185-192</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32170560</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2005 Aug;11(8):875-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16007097</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Liver Int. 2020 Jun;40(6):1321-1326</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32239591</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Transl Hepatol. 2020 Mar 28;8(1):18-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32274342</ArticleId>
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<affiliations><list><country><li>Espagne</li>
<li>France</li>
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<region><li>Catalogne</li>
<li>Languedoc-Roussillon</li>
<li>Occitanie (région administrative)</li>
<li>Pays de la Loire</li>
<li>Île-de-France</li>
</region>
<settlement><li>Angers</li>
<li>Barcelone</li>
<li>Le Chesnay</li>
<li>Montpellier</li>
<li>Nîmes</li>
<li>Paris</li>
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</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Lamazou, F" sort="Lamazou, F" uniqKey="Lamazou F" first="F" last="Lamazou">F. Lamazou</name>
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<name sortKey="Cales, P" sort="Cales, P" uniqKey="Cales P" first="P" last="Calès">P. Calès</name>
<name sortKey="Cales, P" sort="Cales, P" uniqKey="Cales P" first="P" last="Calès">P. Calès</name>
<name sortKey="Delaroche, L" sort="Delaroche, L" uniqKey="Delaroche L" first="L" last="Delaroche">L. Delaroche</name>
<name sortKey="Delaroche, L" sort="Delaroche, L" uniqKey="Delaroche L" first="L" last="Delaroche">L. Delaroche</name>
<name sortKey="Descamps, P" sort="Descamps, P" uniqKey="Descamps P" first="P" last="Descamps">P. Descamps</name>
<name sortKey="Descamps, P" sort="Descamps, P" uniqKey="Descamps P" first="P" last="Descamps">P. Descamps</name>
<name sortKey="Letouzey, V" sort="Letouzey, V" uniqKey="Letouzey V" first="V" last="Letouzey">V. Letouzey</name>
<name sortKey="Octernaud, S" sort="Octernaud, S" uniqKey="Octernaud S" first="S" last="Octernaud">S. Octernaud</name>
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<name sortKey="Place, V" sort="Place, V" uniqKey="Place V" first="V" last="Place">V. Place</name>
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<country name="Espagne"><noRegion><name sortKey="Dieli Crimi, R" sort="Dieli Crimi, R" uniqKey="Dieli Crimi R" first="R" last="Dieli-Crimi">R. Dieli-Crimi</name>
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<name sortKey="Dieli Crimi, R" sort="Dieli Crimi, R" uniqKey="Dieli Crimi R" first="R" last="Dieli-Crimi">R. Dieli-Crimi</name>
<name sortKey="Guerin, A" sort="Guerin, A" uniqKey="Guerin A" first="A" last="Guerin">A. Guerin</name>
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	Serveur d'exploration COVID et hydrochloroquine
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COVID-19 infection in first trimester of pregnancy marked by a liver cytolysis in a woman previously treated by hydroxychloroquine for repeated implantation failure: a case report.

COVID-19 infection in first trimester of pregnancy marked by a liver cytolysis in a woman previously treated by hydroxychloroquine for repeated implantation failure: a case report.

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